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. 2015 Dec 22;15(3):455–470. doi: 10.1080/15384101.2015.1127478

Figure 9.

Figure 9.

ARTIK-52 inhibits replication and causes accumulation of cells in S-phase of cell cycle. A, B. EdU incorporation in ARTIK-52 sensitive MCF7 (A) or resistant MDA-MB-231 (B) cells treated with 1 μM of ARTIK-52 for 9 hours. EdU was added for the last 2 hours of incubation. C. Quantitation of EdU staining shown on panels A and B done by counting of EdU positive and DAPI positive cells in 10 fields of view (10X magnification). Error bars – standard deviation between % of EdU positive cells in 10 fields. D. FACS analysis of cell cycle distribution of CWR22R cells before and after treatment with 1 µM of ARTIK-52 quantitated ModFit LT (Verity Software House). Error bars are deviations between 2 replicates within one experiment.