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. 2015 Dec 22;15(3):394–402. doi: 10.1080/15384101.2015.1127470

Figure 1.

Figure 1.

LNCaP cells were more sensitive in response to doxorubicin than PC3 cells. (A) LNCaP cells showed 4- to 8- fold greater sensitivity than that of PC3 cells to doxorubicin treatment in apoptosis. LNCaP and PC3 cells were cultured and treated with various concentrations of doxorubicin as indicated for 48 hr. Immunoblot analysis of cell lysates were used to detect the activated form of caspase 3 and PARP with cleavage PARP. Experiments were repeated 3 times and representative results are shown. Doxo: doxorubicin. Caspase 3(a): the activated form of caspase 3. (B) Doxorubicin induced significant cell death in LNCaP cells, but not in PC3 cells. Flow cytometric analyses of PC3 or LNCaP cells treated by doxorubicin for 24 and 48 hours. Analyses were in triplicate and representative histograms are shown. X- and Y-axes represent DNA content and cell numbers, respectively.