Table 2. Incidence of congenital heart disease (CHD) subtypes (per 1,000) in Guangdong Registry of Congenital Heart Disease (GRCHD) compared with European Registry of Congenital Anomalies (EUROCAT) and Hoffman’s review.

Subtypes of CHD	GRCHD 2004–2012	EUROCAT 2000–2005	Hoffman et al. 1955–2001
	[95% CI]		Median	Upper quartile
Left-to-right shunt
Ventricular septal defect	3.71 [3.56, 3.86]	3.06	2.83	4.48
Patent ductus arteriosus	3.16 [3.02, 3.30]	NA	0.57	0.78
Atrial septal defecta	2.89 [2.76, 3.02]	2.05	0.56	1.06
Atrioventricular septal defect	0.28 [0.23, 0.32]	0.19	0.34	0.40
Pulmonary outflow tract obstruction
PS/PVS	0.69 [0.63, 0.76]	0.40	0.53	0.84
Tetralogy of Fallot	0.32 [0.27, 0.36]	0.28	0.36	0.58
Pulmonary atresia	0.09 [0.07, 0.12]	0.09	0.08	0.15
Left ventricular outflow tract obstruction
Coarctation of the aortab	0.13 [0.11, 0.16]	0.34	0.36	0.49
Aortic stenosis/aortic valve stenosisb	0.07 [0.05, 0.09]	0.14	0.26	0.39
Hypoplastic left heart syndromeb	0.08 [0.06, 0.10]	0.26	0.23	0.28
Transposition of the great arteries (TGA)
TGA	0.43 [0.38, 0.48]	0.35	0.30	0.39
Condition with intra cardiac mixing
Double outlet of right ventricle	0.28 [0.24, 0.32]	NA	0.13	0.25
TAPVC	0.10 [0.08, 0.12]	0.05	0.09	0.12
Common arterial truncusb	0.04 [0.03, 0.06]	0.09	0.09	0.14
Others
Mitral insufficiency	0.23 [0.19, 0.27]	NA	NA
Single ventricle	0.14 [0.11, 0.16]	0.07	0.09	0.14
Dextrocardia	0.10 [0.08, 0.13]	NA	NA
Hypoplastic right heart syndrome	0.10 [0.07, 0.12]	0.04	0.16	0.22
Ebstein’s anomaly	0.06 [0.04, 0.08]	0.05	0.04	0.16
Persistent left superior vena cava	0.06 [0.04, 0.08]	NA	NA
Pulmonary valve insufficiency	0.05 [0.03, 0.08]	NA	NA
Tricuspid valve atresiab	0.05 [0.03, 0.06]	0.08	0.09	0.12
Mitral stenosis	0.04 [0.02, 0.05]	NA	NA

Abbreviations: NA = Data not available; PS/PVS = pulmonary stenosis or pulmonary valve stenosis; TAPVC = total anomalous pulmonary venous connection.

^a The incidence of CHD subtype was higher in GRCHD.

^b The incidence of CHD subtype was lower in GRCHD.