Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Role of promoter region DNA methylation on gene expression. Upper panel depicts a gene promoter with unmethylated cytosine-phosphate-guanine (CpG) dinucleotides (open circles), allowing access to transcription binding sites and the opportunity for gene expression. Lower panel depicts methylated CpG dinucleotides (filled circles), which would block transcription factor binding and thus repress gene expression.
