Table 1.
Quantitative Characterization of pH-DENs and Non-pH-DENs
| feed
|
IONC
|
sorafenib
|
|||||
|---|---|---|---|---|---|---|---|
| pH-ADTa (mg) | IONCb (mg) | sorafenibc (mg) | loading efficiencyd (%) | contentsd (wt %) | loading efficiencye (%) | contentse (wt %) | |
| pH-DENs | 10 | 1.0 | 20 | 66.0 ± 4.3 | 0.66 ± 0.04 | 73.3 ± 2.5 | 14.66 ± 0.50 |
| non-pH-DENs | 1.0 | 20 | 63.2 ± 6.4 | 0.63 ± 0.06 | 52.3 ± 4.0 | 10.47 ± 0.81 | |
a
Weight of feed pH-ADT per 100 mg of PLGA.
b
Weight of feed iron oxide nanocubes (IONC) per 100 mg of PLGA.
c
Weight of feed sorafenib per 100 mg of PLGA.
d
Encapsulation efficiency = (actual mass of IONC or sorafenib/feed mass of IONC or sorafenib) × 100, as determined by ICPOES.
e
Loading contents = (actual mass of IONC or sorafenib/actual total mass of NCS) × 100, as determined by HPLC (n = 3).