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. Author manuscript; available in PMC: 2017 Jan 15.
Published in final edited form as: ACS Chem Biol. 2015 Nov 6;11(1):121–131. doi: 10.1021/acschembio.5b00847

Figure 2.

Figure 2

A derivatizable, promiscuous inhibitor of protein kinases. (A) (Top panel, left) A previously reported promiscuous ATP-competitive kinase inhibitor (1). (Top panel, right) The pan-kinase inhibitor scaffold used in the design of the bivalent inhibitors in this study retains a broad spectrum of kinase inhibition as assessed by KINOMEscan (Figure S1). (Bottom panel) A crystal structure of a quinazoline derivative of 1 bound to the kinase Src suggests a site for linker attachment. PDB ID 3F6X. (B) Reagents based on the pan-kinase inhibitor 1.