FIGURE 4.

(A) Liver of control rat showing normal hepatocytes; x 10. (B) Liver of rat treated with CCl₄ showing formation of septa, bridging necrosis and dense periportal inflammation; x 10. (C) Liver of rat treated with CCl₄ and 100 mg/kg Silymarin showing complete absence of periportal inflammation or necrosis; x 400. (D) Liver of rat treated with CCl₄ and 400 mg/kg of RD methanol leaf extract showing mild periportal inflammation; x 10. (E) Liver of rat treated with CCl₄ and 400 mg/kg RD methanol bark extract showing reversal of changes with absence of periportal inflammation or necrosis; x 10. N, normal hepatocytes; Ne, necrotic cells; MI, mild inflammation.