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. 2016 Jul 14;7:303. doi: 10.3389/fphys.2016.00303

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Copyright © 2016 Mancinelli, Di Filippo, Verratti, Fulle, Toniolo, Reggiani and Pietrangelo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The graphs show the relative expression of miR-1, miR-133b, and miR-206 before (PRE) and after (POST) Hymalaia expedition in cells with increased (A) and reduced (B) superoxide production. The analysis were performed on undifferentiated and differentiated cells. (A) In oxidized cells, both in undifferentiated and differentiated conditions, the cells showed a down-regulation of miRNA 133b and miRNA 206. miRNA-1 was down-regulated in POST-Hypoxia differentiated cells while up-regulated in undifferentiated cells, comparing to PRE-Hypoxia. (B) In non-oxidized cells both in undifferentiated and differentiated conditions POST-Hypoxia cells showed an up-regulation of all tested miRNAs compared to PRE-Hypoxia cells. The independent experiments were performed in triplicates. ^*p < 0.05 and ^***p < 0.0001.