Table 3.

Genes down-regulated more than 10-fold (p < 0.01) in the liver of vaccinated mice infected with P. chabaudi on day 11 p.i. (Vd11) in comparison to constitutive expression on day 0 p.i. (Vd0).

Gene	Gene description	RefSeq ID Agilent ID	Vd11 vs. Vd0	p-value	Function (according to www.genecards.org)
Cd163	CD163 antigen	NM_053094 A_55_P2289819	0.02	0.002	“The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation.”
Dbp	D site albumin promoter binding protein	NM_016974 A_55_P2032081	0.06	<0.001	“The protein encoded by this gene is a member of the PAR bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, CYP2A4, and CYP2A5.”
Lifr	Leukemia inhibitory factor receptor	NM_001113386 A_55_P2159264	0.06	<0.001	“Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.”
Ncmap	Noncompact myelin associated protein	NM_001243306 A_55_P2095039	0.08	0.005	“Plays a role in myelin formation.”
Slc27a6	Solute carrier family 27 (fatty acid transporter), member 6	NM_001081072 A_55_P2039379	0.09	0.005	“Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane.”