Table 5.
Selected miRNAs and their predicated target genes
| MicroRNAs | Predicted targets |
|---|---|
| Upregulated miRNAs | |
| miRNA-222 | TRPS1, CERS2, RECK, DICER1, ETS1, DIRAS3, TCEAL1, CORO1A, TP53, SELE, PTEN, BBC3, ESR1, Kit, ICAM1, FOS Bcl2l11, Cdkn1b, TNFSF10, TIMP3, PPP2R2A, TMED7, Cdkn1c, FOXO3, MMP1, SOD2, STAT5A |
| miRNA-221 | CDKN1B, BCL2L11, BMF, FOXO3, Cdkn1c, kit, Psmd9, HOXB5, TMED7, DDIT4, BNIP3L, TBK1, MYBL1, DKK2, CREBZF, BRAP, USP18, ARIH2, BBC3, HMGXB4, TIMP3, TNFSF10, ICAM1, FOS, DDIT4, BNIP3, NAIP, ESR1, TICAM1, MDM2, PTEN, SELE, TP53, CORO1A, TCEAL1, DIRAS3, ETS1, DICER1, TRPS1, CERS2, SOX9, FN1 |
| miRNA-21 | BTG2, CDKAP1, PDCD4, LRRFIP1, CDC25A, PELI1, PDCD4, TP63, PTEN, HNRPK, TGFBR2, TGFBR2, SMARCA4, SPRY1/2, PRARA, TIMP3, RHOB, MSH2/6, ANP32A, BCL2, ANP32A, BMPR2, MARCK5, ANKRD46, RECK |
| miRNA-210 | TCF7L2, HOXA9, TP53I11, PIM1, HOXA1, FGFRL1, RAD52, NPTX1, EFNA3, BDNF, PTPN1, P4HB, UBQLN1, SERTAD2, SEH1L, NCAM1, MID1IP1, MDGA1, KIAA1161, ISCU, HOXA3, GPD1L, DENND6A, CPEB2, CDK10, ABCB9, CBX1, XIST, TNPO1, SMCHD1, PTAR1, NIPBL, MIB1, HECTD1, ELK3, DDAH1, CLASP2, CHD9, ATP11C, APC, E2F3, ACVR1B, MRE11A, XPA, UCP2, MNT, AIFM3, CASP8AP2, VMP1, TFRC, NFKB1, BCL2 |
| miRNA-224 | KLK10, CXCR4, CDC4, AP2M1, NIT1, FOSB, NCOA6, API5, EYA4, EDNRA, DIO1, SMAD4, PEBP1 |
| Downregulated miRNAs | |
| miRNA-99a | RAVER2, FGFR3, SERPINE1, IGF1R, mTOR, SNF2H |
| miRNA-199a | SIRT1, HIF1A, MET, KRT7, CD44, EZH2, IKBKB, CCNL1, MAPK9, MAPK1, AKT1, MAPK8, MAPK14, LIF, DDR1, EDN1, MAP3K11, HIF1A, SOX9, FUT4, UBE2G1, UBE2I, SMARCA2, SMAD1, RUNX1, COX2, CAV2, TMEM54, SMAD4, SULT1E1, GPR78, ERBB2, UNG, CAV1, ET1 |
| miRNA-195 | WEE1, E2F3, CDK6, CCND1, ARL2, CCND1, VEGFA, CCL4, KRT7, BCL2, RAF1, RUNX2, SLC2A3, TBCCD1, CCND3, CDK4, SIRT1, BACE1, CDC42, CAB39, CHUK, TAB 3, MBD1, CCNE1, BCL2L2, ARL2 |
| miRNA-125b | BMPR1B, EIF4EBP1, HMGA2, HMGA1, GLI1, NKIRAS2, TP53, SMO, VDR, SGPL1, BAK1, ERBB3, ERBB2, BMF, KLF13, NTRK3, LIN28A, CBFB, AKT1, CYP24A1, RAF1, SMO, PRDM1, IRF4, GRIN2A, CDKN2A, LIN28A, MAP2K7, JUB, KRT7, TNF, TP53INP1, E2F3, TRIM71, IGF2, LIN28B, BAK1, BBC3, BMF, KLF13, TEF, STAT3, BAK1, JUN, JUND, PPP1CA, PPKRA, PRKRA, PPP1CAB, SRF, NKX2-5, PRPF8, BCL2, ETS1, RPS6KA1, TNFAIP3, PIGF, BCL3, TBC1D1, DGAT1, FGFR2, SUV39H1, ARID3B, SMAD4, MCL1, IL6R, STARD13, ABTB1, CBFB, HK2, MMP13, SNAI1, MAPK14, MUC1, NES |