Fig. 6.

Effects of adenosine and BAY 60-6583 on the whole-cell current in Capan-1 single cells. a Representative current-voltage relationships for the whole-cell current. The current was elicited by a voltage ramp from −123 to +37 mV with a rate of 0.2 V/s. Adenosine (Ado) increased the current in the NaCl-rich bathing solution (c). Thereafter, the current induced by adenosine decreased by CFTRinh-172 (172). b Concentration-response curve for adenosine at −83 mV. The solid line is the fit by the Hill equation (n = 5). c The representative trace demonstrates the increase observed in the inward current at −83 mV in response to BAY 60-6583 (10 μM) and the inhibition by CFTRinh-172 (172; 20 μM). d Representative current-voltage relationships for the whole-cell current from the same recording shown in c. BAY 60-6583 increased the current in the NaCl-rich bathing solution (c). Thereafter, the current induced by BAY 60-6583 decreased by CFTRinh-172 (172)