Table 1. Patient demographic and tumor characteristics per chemotherapy regimens prior to bevacizumab.
Variable | <3 Prior regimens (n=29) | ≥3 Prior regimens (n=31) | p-value | |
---|---|---|---|---|
Race | 0.63 | |||
White | 22 (75.86) | 26 (83.87) | ||
Black | 3 (10.34) | 1 (3.23) | ||
Hispanic | 2 (6.9) | 2 (6.45) | ||
American-Indian | 0 | 1 (3.23) | ||
Unknown | 2 (6.9) | 1 (3.23) | ||
Age at start of bevacizumab (yr) | 57 (37–83) | 60 (35–79) | 0.98 | |
BMI at bevacizumab start (kg/m2) | 26.56 (16.65–39.39) | 24.67 (18.61–42.58) | 0.85 | |
Stage | 0.36 | |||
IA–IIIC | 1 (3.44) | 2 (6.5) | ||
IIA–IV | 28 (96.6) | 29 (93.5) | ||
Histology | 0.50 | |||
Serous | 20 (68.97) | 18 (58.1) | ||
Adenocarcinoma | 8 (27.59) | 10 (32.26) | ||
Clear cell, mixed | 1 (3.44) | 3 (9.68) | ||
Debulking | 0.51 | |||
Optimal | 18 (62.07) | 22 (70.97) | ||
Platinum resistant | 0.99 | |||
Yes | 15 (51.72) | 16 (51.61) | ||
Prior radiation to abdominopelvic area | 0.93 | |||
Yes | 3 (10.34) | 3 (9.68) | ||
Prior bowel surgery | 0.61 | |||
Yes | 14 (48.28) | 17 (54.84) | ||
Time from bowel surgery to start of bevacizumab (mo) | 23.11 (8.17–41.6) | 45.93 (21.2–103.07) | <0.001 | |
Bevacizumab combined with cytotoxic chemotherapy | 0.24 | |||
Yes | 21 (72.41) | 18 (58.06) | ||
Number of prior cytotoxic regimens | 2 (2) | 3 (3-9) | <0.001 | |
Number of bevacizumab doses | 9 (3–45) | 10 (2–33) | 0.97 | |
Cumulative bevacizumab received (mg) | 8,800 (1,440–81,525) | 10,000 (1,710–36,300) | 0.63 | |
Follow-up after last dose of bevacizumab (mo) | 11.3 (1.47–60.4) | 10.73 (0.27–51.3) | 0.60 |
Values are presented as number (%) or median (range).
BMI, body mass index.