Table 4.
Analyses of association between CR2 gene haplotypes and the risk of ONFH in SLE patients.
| Haplotype | Genotype | Frequencies (%) | Allele | Dominant | Recessive | ||||
|---|---|---|---|---|---|---|---|---|---|
| SLE | SLE_ONFH | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | ||
| Block1-ht1 T-G-C-G-A |
−/− | 46 (32.86) | 22 (45.83) | ||||||
| ht1/− | 71 (50.71) | 21 (43.75) | 0.66 (0.41–1.08) | 0.10 | 0.58 (0.30–1.13) | 0.106 | 0.59 (0.21–1.65) | 0.313 | |
| ht1/ht1 | 23 (16.43) | 5 (10.42) | |||||||
|
| |||||||||
| Block1-ht2 T-G-T-G-G |
−/− | 74 (52.86) | 31 (64.58) | ||||||
| ht2/− | 58 (41.43) | 14 (29.17) | 0.73 (0.42–1.28) | 0.275 | 0.62 (0.31–1.21) | 0.158 | 1.1 (0.28–4.33) | 1.0 | |
| ht2/ht2 | 8 (5.71) | 3 (6.25) | |||||||
|
| |||||||||
| Block1-ht3 T-G-T-G-A |
−/− | 96 (68.57) | 28 (58.33) | ||||||
| ht3/− | 38 (27.14) | 13 (27.08) | 1.8 (1.05–3.09) | 0.031 | 1.56 (0.79–3.06) | 0.196 | 3.81 (1.21–12.0) | 0.023∗ | |
| ht3/ht3 | 6 (4.29) | 7 (14.58) | |||||||
|
| |||||||||
| Block1-ht4 C-C-T-A-A |
−/− | 101 (72.14) | 35 (72.92) | ||||||
| ht4/− | 39 (27.86) | 10 (20.83) | 1.24 (0.66–2.33) | 0.512 | 0.96 (0.46–2.01) | 0.918 | 0.016∗ | ||
| ht4/ht4 | 0 (0.0) | 3 (6.25) | |||||||
(i) SNP order of haplotypes: rs3813946 (T/C)-rs311306 (G/C)-rs1567190 (T/C)-rs17615 (G/A)-rs17045328 (A/G).
(ii) Haplotype distributions are shown as number (%). Chi-square P values and odds ratio (95% CI) are shown. OR: odds ratio; CI: confidence interval.
(iii) ∗Fisher's exact test.