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. Author manuscript; available in PMC: 2016 Jul 14.
Published in final edited form as: Rapid Commun Mass Spectrom. 2013 Jun 30;27(12):1294–1302. doi: 10.1002/rcm.6572

Table 1.

Plasma apo(a) concentrations, fractional synthesis rate (FSR), and production rate (PR) from three human subjects. Note that the change in isotope labeling of apo(a) reflects the incorporation of two leucines; therefore, calculation of FSR requires dividing by 2 (see Experimental section). The literature values reported here were expressed as FCR, which we have assumed a metabolic steady state (i.e., FSR = FCR) for purposes of comparison

apo(a) Subject 6 Subject 3 Subject 11 Literature values
Plasma concentration (nM) 211.9 199.7 68.8
Change in isotope labeling (slope/h) 0.062     0.056   0.129
VLDL-apoB leucine enrichment (%) 5.25     4.57   4.20
FSR (pools/day) 0.128     0.164   0.368 0.22; 0.24; 0.25a
production rate (nmol/kg/day) 1.22     1.47   1.14
a

Jenner et al.;[11] Demant et al.;[13] Frischmann et al.[12]