Figure 5.

Repeated asenapine (ASE) treatment increased the suppression of avoidance response in adolescent rats (postnatal days, P 43–48) (a) and increased sensitivity to ASE re-exposure in the challenge test in adulthood (P ~76) (b). Number of avoidance responses made by the rats from the ASE (0.05 mg/kg), ASE (0.10 mg/kg), ASE (0.20 mg/kg) and vehicle groups on the last training (pre-drug) day, during the five drug test days and on the challenge test day are expressed as mean+standard error of the mean (SEM). **p<0.004, three ASE groups relative to the VEH group; #p<0.05, ASE 0.10 and ASE 0.20 groups relative to the ASE 0.05 group, respectively. Adapted from Shu Q, Qin R, Chen Y, et al. (2014b) Asenapine sensitization from adolescence to adulthood and its potential molecular basis. Behav Brain Res 273: 166–176 with permission from Elsevier.

VEH: vehicle.