Table 1. Detection of C.albicans in fetal blood and gut tissue, and IL-6 plasma levels.
| Control | Fluconazole | 3d C.albicans | 3d C.albicans + 1d Fluc | 5d C.albicans + 3d Fluc | |
|---|---|---|---|---|---|
| Positive C.albicans blood culture | 0/6 (0%) | 0/3 (0%) | 5/7 (71%)*OR: 28.6 95% CI (1.12–731.54) | 5/6 (83%) *OR: 47.67 95% CI (1.6–1422.69) | 3/5 (60%) |
| Positive PAS staining for Candida in the gut | 0/6 (0%) | 0/3 (0%) | 6/7 (86%)**OR: 56.33 95% CI (1.92–1655) | 2/6 (33%) | 1/5 (20%)$ OR: 0.033 95% CI (0.001–0.68) |
| IL-6 (ng/mL) | N.D. | N.D. | 40 ± 45*,# | N.D. | 19 ± 29 |
For the detection of C.albicans in blood cultures and gut, the results were analyzed by Fisher’s Exact Test. Data are presented as positive/total number of animals.
For IL-6 results, differences between groups were analyzed by non-parametric Kruskal Wallis tests followed by Dunn’s multiple comparisons test. Data are presented as mean ± SD.
*p < 0.05, **p < 0.01 compared to control. #p < 0.05 compared to 3d C.albicans + 1d Fluc group, $p < 0.05 compared to 3d C.albicans. CI, confidence interval; Fluc, fluconazole; IL, interleukin; n, number; N.D., not detectable; OR, odds ratio; PAS, Periodic acid–Schiff.