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. Author manuscript; available in PMC: 2016 Jul 14.
Published in final edited form as: J Med Chem. 2015 Jun 16;58(12):5015–5027. doi: 10.1021/acs.jmedchem.5b00449

Table 3.

Growth Inhibitory Activity (GI50, μM) of B-ring Modified 3-Benzyl-4-chromanone Analogs. 95% Confidence Interval Shown in Parentheses.

graphic file with name nihms-799183-f0024.jpg
Cpd B ring HREC HUVEC 92-1 Y79
12a graphic file with name nihms-799183-t0025.jpg >100 >100 >100 >100
12b graphic file with name nihms-799183-t0026.jpg 1.1 (0.29 – 4.4) 0.51 (0.11 – 25) >100 >100
12c graphic file with name nihms-799183-t0027.jpg 18 (6.1 – 50) 17 (5.1 – 57) >100 40 (24 – 66)
12d graphic file with name nihms-799183-t0028.jpg >100 92 (27 – 317) >100 >100
12e graphic file with name nihms-799183-t0029.jpg 22 (13 – 40) >100 61 (14 – 278) 20 (8.1 – 51)
12f graphic file with name nihms-799183-t0030.jpg 0.65 (0.26 – 1.6) >100 >100 >100
12g graphic file with name nihms-799183-t0031.jpg 0.17 (0.030 – 0.97) >100 >100 >100
12h graphic file with name nihms-799183-t0032.jpg 0.22 (0.064 – 0.77) 38 (13 – 109) >100 >100
12i graphic file with name nihms-799183-t0033.jpg 49 (17 – 141) >100 >100 24 (6.1 – 97)