Table 4.
Growth Inhibitory Activity (GI50, μM) of Homoisoflavonoids Comprising Amino Acids on the C3′ Position of the B-Ring. 95% Confidence Interval Shown in Parentheses.
| |||||
|---|---|---|---|---|---|
| Cpd | B ring | HREC | HUVEC | 92-1 | Y79 |
| 14a |
|
0.055 (0.032 – 0.094) | 0.75 (0.37 – 1.5) | >100 | 12 (5.7 – 25) |
| 14b |
|
0.51 (0.26 – 1.0) | >100 | >100 | >100 |
| 14c |
|
0.16 (0.020 – 1.3) | 0.091 0.013) – 0.63) | >100 | 52 17 – 166 |
| 14d |
|
3.1 (1.3 – 7.4) | >100 | >100 | 24 (7.1 – 79) |
| 14e |
|
0.13 (0.026 – 0.69) | >100 | >100 | >100 |
| 14f |
|
0.17 (0.035 – 0.82) | >100 | >100 | >100 |
| 14g |
|
0.14 (0.027 – 0.73) | >100 | >100 | >100 |
| 14h |
|
1.0 (0.031 – 3.6) | 34 (7.2 –165 | 98 (37 – 265) | 48 (33 – 69) |
| 14i |
|
1.4 (0.73 – 2.4) | >100 | >100 | 64 (26 –158) |
| 14j |
|
1.5 (0.41 – 5.4) | 22 (11 – 43) | >100 | >100 |
| 15a |
|
22 (16 – 32) | 8.6 (1.2 – 6.1) | 3.1 (0.93 – 10) | 4.7 (1.2 – 18) |
| 15b |
|
>100 | >100 | >100 | 0.39 (0.12 – 1.3) |
| 15c |
|
13 (9.7 – 17) | 4.5 (1.2 – 17) | 1.9 (0.65 – 5.3) | 2.5 (1.4 – 4.6) |