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. 2016 Jul 14;6:29714. doi: 10.1038/srep29714

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Cases depicted in panels A–C were selected due to loss of expression of ATRX and DAXX as a surrogate marker of ALT positivity; these cases presented large, ultrabright and unbalanced size telomere FISH signals (marked by the arrows), a phenotype indicative of ALT. Panels D–F, represent TERTp mutated cases 1, 3 and 4, respectively. In these cases, although some robust telomeres were present, we did not detect ultra-bright foci and the telomeres were balanced in size. One of the TERTp mutated cases was excluded from this analysis (case 2) for technical reasons, since no Tel-FISH signal was detected.