FIG 6.

Mouse challenge study against avian influenza virus A/Ck/Egypt/01/08 comparing the mosaic HA vaccine (MVA-H5M) and the native HA vaccine (MVA-HA). (A) Neutralizing antibodies were elicited by MVA-H5M but not by MVA-HA. (B) Both MVA-H5M and MVA-HA protected against influenza virus A/Ck/Egypt/01/08 challenge. (C and D) Mice vaccinated with MVA-H5M vaccine showed no weight loss and no nasal or lung viral titers compared to mice vaccinated with MVA-HA, which showed morbidity with significant weight loss and nasal and lung viral titers. Three mice from each group were sacrificed at day 5 postchallenge for determination of the nasal and lung titers.