Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
ISG12a restricts viral infection through the ubiquitination-dependent degradation pathway. ISG12a targets NS5A for ubiquitination-dependent proteasomal degradation in HCV-infected cells. SKP2 is involved in ISG12a-induced ubiquitination and degradation of viral protein. ISG12a as a crucial adaptor links SKP2 to NS5A for restriction of viral infection. Ub, ubiquitin.
