TABLE 4.

Relationship between viral infection status and plasma cytokine concentrations in South African vervet monkeys^a

Virus	Cytokine	t value for cytokine	P value (uncorrected) for cytokine	P (corrected) for cytokine	Model covariate	t value for model covariate	P value (uncorrected) for model covariate	P (corrected) for model covariate
DMVV-1	EGF	2.27	0.040	>1.0	Age	−2.07	0.040	>1.0
	GM-CSF	3.19	0.002	0.05	Age	−0.27	0.788	>1.0
					Sex (male)	2.22	0.029	0.81
	IL-1β	2.29	0.024	0.67	Age	−2.42	0.017	0.48
					Sex (male)	3.19	0.002	0.05
	IL-10	2.36	0.020	0.56	Sex (male)	1.71	0.089	>1.0
	MCP-1	1.95	0.049	>1.0	Age	−2.05	0.043	>1.0
					Sex (male)	3.83	<0.01	<0.01
	MIP-1β	3.09	0.003	0.07	Age	−2.53	0.012	0.36
	TNF-α	2.10	0.038	>1.0	Sex (male)	2.10	0.038	>1.0
SPgVver	MIG	−2.24	0.027	0.76	Sex (male)	4.06	<0.01	<0.01
					SIV	−0.84	0.404	>1.0
					SIV*SPgV	2.46	0.016	0.43
SIVver	IFN-γ	−2.79	0.006	0.18
	IL-6	1.79	0.043	>1.0	SPgV	−1.19	0.236	>1.0
					SIV*SPgV	1.52	0.131	>1.0
	I-TAC	2.20	0.030	0.84
	MIF	2.15	0.034	0.95	Age	−2.14	0.034	0.95

^aA multivariate linear model was developed, and model covariates were identified by using stepwise backward elimination. Uncorrected P values are those inferred by the model. Corrected P values represent Bonferroni-corrected P values for a total of 28 hypotheses tested (one for each cytokine). For a full list of cytokines tested, see Table S1 in the supplemental material.