TABLE 3.

R2^* Slope Estimates From the Liner Mixed-Effects Growth Model

	Group No	IM	ISOM	OSOM	CO
Iothalamate	1	0.10	0.91 *†‡	0.06	−0.01
Iothalamate_ctrl	2	0.03	0.07	−0.04	−0.03
Iohexol	3	0.15	0.66 *†‡	0.09	−0.01‡
Iohexol_ctrl	4	0.24†	0.24†	0.02	0.25†
Iodixanol	5	0.45 *†‡	0.73 *†	0.17†	0.08†‡
Iodixanol_ctrl	6	1.16 †	0.49 †	0.16†	0.19†
Ioxalgate	7	0.32†	0.88 *†‡	0.29*†‡	0.04
Ioxalgate_ctrl	8	0.26†	0.04	0.05	−0.05
Placebo	9	0.12	0.27†	0.11†	0.05
Placebo_ctrl	10	−0.01	−0.04	−0.06	0.01

Pretreated animals receiving saline (group 9) showed a significant change in slope in ISOM; however, NGAL showed no increase in this group at 4 hours. We used this as a reference slope and a defined slope of greater than 0.3 and reaching statistical significance to be physiologically relevant. These values are shown in BOLD. In general, the slope estimates are higher in the CIAKI-susceptible group compared with the control group in IOSM.

^*A significant change in slope compared with group 9 (P < 0.05).

^†Slope is significantly different from zero (P < 0.05).

^‡A significant change in slope compared with the control group (P < 0.05).

CO indicates cortex; ctrl, control; IM, inner medulla; ISOM, inner stripes of the outer medulla; OSOM, outer stripes of the outer medulla.