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(A) Chemical structures of moxifloxacin and GSK299423 (B) the crystal structure of gyrase (purple) bound to DNA (backbone shown in orange) and two copies of GSK299423 (cyan) from PDB ID: 2XCS [23]. The figure shows a superposition of moxifloxacin (green) from PDB ID: 3FOF [22]. Typical resistance mutations are shown in magenta.
