Fig. 4.

Sequencing confirms BK virus infection in brain tissue and identifies unique BKV_N NCCR region. a Sequence analysis of BKV_N NCCR region. Start codon for the late coding region is shown by red arrow. The origin of viral replication (ori) and TATA box are depicted. T-Ag binding sites are underlined. The BKV_N P blocks appear in two variants consisting of 41 (ΔP41) and 25 (ΔP26) nucleotides are shown in blue or red, respectively. Each of these blocks is similar to the initial portion of P block of archetype. Insertions/variations are also highlighted (pink). b Schematic comparison of NCCR sequence between BKV archetypal and BKV_N. The NCCR region of the archetypal BKV contains five sequence blocks denoted O-143 (with ori), P-68, Q-39, R-63 and S-63 where the numbers indicate base pairs. The BKV_N NCCR contains block O-143, two tandem repeats composed of portions of block P (ΔP41 and ΔP26) and separated by polyA stretch. Blocks Q and R follow the second ΔP26