Table 2.

Treatment-Related Preoperative Grade 3 or 4 Adverse Events

Adverse Event	Grade 3	Grade 4
Hematologic
Leukopenia	6 (15.0 %)	2 (5.0 %)
Neutropenia	3 (7.5 %)	2 (5.0 %)
Anemia requiring blood transfusion	2 (5.0 %)
Febrile neutropenia	1 (2.5 %)	2 (5.0 %)
Thrombocytopenia		1 (2.5 %)
Gastrointestinal
Dysphagia, esophagitis, odynophagia	7 (17.5 %)	1 (2.5 %)
Anorexia	7 (17.5 %)
Dehydration	7 (17.5 %)
Nausea	6 (15.0 %)
Diarrhea	4 (10.0 %)
Vomiting	4 (10.0 %)
Abdominal pain or cramping	2 (5.0 %)
Systemic
Fatigue	3 (7.5 %)
Hypotension	3 (7.5 %)	1 (2.5 %)
Hyperbilirubinemia	1 (2.5 %)
Creatinine Elevation	1 (2.5 %)
Chest pain (non-cardiac)	1 (2.5 %)
Supraventricular arrhythmia	1 (2.5 %)
Syncope	1 (2.5 %)
Thrombosis/embolism		1 (2.5 %)