Skip to main content
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1973 Oct;36(5):736–741. doi: 10.1136/jnnp.36.5.736

Effect of carotid ligation on cerebral blood flow in baboons 1

1. Response to altered arterial PCO2

D Sengupta 1,2, Murray Harper 1,2,2, B Jennett 1,2
PMCID: PMC494450  PMID: 4201868

Abstract

Measurements of cerebral blood flow (CBF) were made in anaesthetized baboons before and after ipsilateral carotid artery ligation and also after bilateral carotid ligation. Results showed that at normocapnia (PaCO2 38-39 mmHg) there was little change in cerebral blood flow on ipsilateral carotid ligation, but when both carotid arteries were tied the blood flow to the brain fell significantly. At hypercapnia (PaCO2 58-60 mmHg) the CBF/CO2 gradient fell significantly on ipsilateral carotid ligation; on bilateral carotid ligation there was only minimal rise in cerebral blood flow in response to the rise in PaCO2. At hypocapnia (PaCO2 20-21 mmHg) the gradients of fall in the CBF were similar before and after ipsilateral carotid ligation; after bilateral carotid ligation there was minimal change in the CBF in response to the fall in the PaCO2. It is suggested that, although cerebral blood flow may be normal after ipsilateral carotid ligation, the circulatory reserve of the brain is not sufficient to meet physiological challenges. This may be the reason for the development of delayed neurological complications after carotid artery ligation.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boysen G., Ladegaard-Pedersen H. J., Henriksen H., Olesen J., Paulson O. B., Engell H. C. The effects of PaCO2 on regional cerebral blood flow and internal carotid arterial pressure during carotid clamping. Anesthesiology. 1971 Sep;35(3):286–300. doi: 10.1097/00000542-197109000-00012. [DOI] [PubMed] [Google Scholar]
  2. DENNY-BROWN D. Recurrent cerebrovascular episodes. Arch Neurol. 1960 Feb;2:194–210. doi: 10.1001/archneur.1960.03840080080013. [DOI] [PubMed] [Google Scholar]
  3. Harper A. M., Deshmukh V. D., Rowan J. O., Jennett W. B. The influence of sympathetic nervous activity on cerebral blood flow. Arch Neurol. 1972 Jul;27(1):1–6. doi: 10.1001/archneur.1972.00490130003001. [DOI] [PubMed] [Google Scholar]
  4. Harper A. M., Glass H. I. Effect of alterations in the arterial carbon dioxide tension on the blood flow through the cerebral cortex at normal and low arterial blood pressures. J Neurol Neurosurg Psychiatry. 1965 Oct;28(5):449–452. doi: 10.1136/jnnp.28.5.449. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hoedt-Rasmussen K., Sveinsdottir E., Lassen N. A. Regional cerebral blood flow in man determined by intra-arterial injection of radioactive inert gas. Circ Res. 1966 Mar;18(3):237–247. doi: 10.1161/01.res.18.3.237. [DOI] [PubMed] [Google Scholar]
  6. Millikan C. H. Cerebral circulation: clinical concepts as effected by vascular anatomy, pathology, and pathophysiology. Clin Neurosurg. 1969;16:419–435. doi: 10.1093/neurosurgery/16.cn_suppl_1.419. [DOI] [PubMed] [Google Scholar]
  7. Nishioka H. Results of the treatment of intracranial aneurysms by occlusion of the carotid artery in the neck. J Neurosurg. 1966 Dec;25(6):660–704. doi: 10.3171/jns.1966.25.6.0660. [DOI] [PubMed] [Google Scholar]
  8. Pistolese G. R., Citon G., Faraglia V., Benedetti-Valentini F J., Pastore E., Semprebene L., De Leo G., Speranza V., Fiorani P. Effects of hypercapnia on cerebral blood flow during the clamping of the carotid arteries in surgical management of cerebrovascular insufficiency. Neurology. 1971 Jan;21(1):95–100. doi: 10.1212/wnl.21.1.95. [DOI] [PubMed] [Google Scholar]
  9. REIVICH M. ARTERIAL PCO2 AND CEREBRAL HEMODYNAMICS. Am J Physiol. 1964 Jan;206:25–35. doi: 10.1152/ajplegacy.1964.206.1.25. [DOI] [PubMed] [Google Scholar]
  10. Symon L., Russell R. W. The development of cerebral collateral circulation following occlusion of vessels in the neck. An experimental study in baboons. J Neurol Sci. 1971 Jun;13(2):197–208. doi: 10.1016/0022-510x(71)90149-3. [DOI] [PubMed] [Google Scholar]
  11. Symon L. The concept of intracerebral steal. Int Anesthesiol Clin. 1969 Fall;7(3):597–615. doi: 10.1097/00004311-196907030-00009. [DOI] [PubMed] [Google Scholar]
  12. Wilkinson I. M. Browne DR: The influence of anaesthesia and of arterial hypocapnia on regional blood flow in the normal human cerebral hemisphere. Br J Anaesth. 1970 Jun;42(6):472–482. doi: 10.1093/bja/42.6.472-a. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES