Table 3.
SNPs genotype distribution in Current Wheezers (CUWH) Vs Controls (NWNA) and HDL-C levels
| SNP (genotype) | NWNA (n, %) | CUWH (n, %) | χ 2 | p value | p trend | HDL mg/dl (mean, 95 % CI) | F | p value | p trend |
|---|---|---|---|---|---|---|---|---|---|
| ADRB2 rs1800888 | |||||||||
| CC | 609 (95 %) | 175 (97.8 %) | 53.3 (52.3–54.2) | ||||||
| CT | 32 (5.0 %) | 4 (2.2 %) | 2.535 | 0.076b | - | 57.2 (51.7–62.8) | 2.840 | 0.092c | - |
| TNFa rs3093664 | |||||||||
| AA | 500 (79.6) | 134 (76.1) | 53.3 (52.2–54.3) | ||||||
| AG | 102 (16.2) | 40 (22.7) | 51.7 (49.4–54.1) | ||||||
| GG | 26 (4.1) | 2 (1.1) | 7.047 | 0.03a | 0.912 | 65.3 (59.2–71.4) | 11.787 | >0.001c | 0.028 |
| PRKCA rs9892651 | |||||||||
| TT | 230 (37.0) | 52 (30.2) | 55.2 (53.4–56.9) | ||||||
| CT | 302 (48,6) | 87 (50.6) | 52.7 (51.4–54.1) | ||||||
| CC | 89 (14.3) | 33 (19.2) | 3.921 | 0.141a | 0.048 | 52.2 (50.0–54.5) | 3.179 | 0.042c | 0.020 |
a χ 2 test (asymptomatic 2- sided significance)
bFischer Exact test (exact 1-sided significance)
cComparisons of means (One way ANOVA)