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. Author manuscript; available in PMC: 2016 Jul 14.
Published in final edited form as: J Alzheimers Dis. 2011;25(2):231–243. doi: 10.3233/JAD-2011-101866

Figure 1. mThy1-hAβPP751 Tg mice display an age-related longitudinal decline in spatial memory and learning in the water maze.

Figure 1

A) Learning curves in the non-Tg and mThy1-hAβPP751 Tg mice at 3 months of age in the water-maze over a four-day test period (D1 to D4). B) Learning curves in the non-Tg and mThy1-hAβPP751 Tg mice at 6 months of age in the water-maze over a four-day test period consisting of a retesting day (RT, where the platform was in the same position as on the last day of testing at 3 months of age) and three days during which the location of the platform was changed from trial to trial (D1 to D3). C) Learning curves in the non-Tg and mThy1-hAβPP751 Tg mice at 9 months of age in the water-maze over a four-day test period consisting of a retesting day (RT, where the platform was in the same position as on the last day of testing at 6 months of age) and three days during which the location of the platform was changed from trial to trial (D1 to D3). Data are represented by means (over four trials, each day) ± SEM.

* Indicates significant difference between non-Tg and mThy1-hAβPP751 Tg mice with p<0.05 by one-way ANOVA; ** Indicates significant difference between non-Tg and mThy1-hAβPP751 Tg mice with p<0.01 by one-way ANOVA.