Table 1. Summary of behavioral differences between mThy-1-751 transgenic and non-transgenic mice by age and gender.
Impairment is stated in case of a significantly worse performance of mThy1-hAβPP751 Tg mice compared to their age-matched non-Tg littermates. ‘Progressive’ means a significant poorer performance as compared to an earlier testing time point. ‘ND’ mice not different at that age (left three columns) or between the testing time points (right three columns).
| Task | 3M | 6M | 9 M | 3 vs. 6 M | 3 vs. 9 M | 6 vs. 9 M |
|---|---|---|---|---|---|---|
| RotaRod | ND | ND | ND | ND | ND | ND |
| Open Field | ||||||
| Activity/Hyperactivity | ND* | ND | ND | ND | ND | ND |
| Thigmotaxis | ND | ND | ND | ND | ND | ND |
| Rearings | ND | ND | ND | ND | ND | ND |
| Poke hole activity | ||||||
| Total activity | ND | increased | increased | ND | increased | increased |
| Hole explorations | ND | increased | increased | increased | increased | ND |
| Water Maze | ||||||
| Water-maze task learning | ND | ND | impaired | ND | ND | ND |
| Water-maze acquisition | impaired | impaired | impaired | progressive | progressive | progressive |
| Water-maze retention | ND | ND | impaired | ND | ND | progressive |
| Probe trial performance | ND | impaired | impaired | progressive | progressive | ND |
| Water-maze Short-term memory |
ND | ND | impaired | ND | progressive | progressive |
*
indicates a gender-specific difference in this parameter, independent from transgenity. “Different” or “increased/decreased” is stated for effects not easily appraisable.