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. 2016 Jul 12;111(1):140–151. doi: 10.1016/j.bpj.2016.05.050

Figure 1.

Figure 1

IAPP fiber-formation kinetics and disruption of DOPC/DPPC LUVs. (A) Fiber formation measured in the presence of 250 μM of 1:2 DOPC/DPPC LUVs containing 0% (black), 20% (red), 30% (blue), and 40% (green) cholesterol. IAPP concentration was 2.5 μM for all samples. (B) IAPP induced release of 6-carboxyfluorescein from LUVs composed of 250 μM (1:2 molar ratio) DOPC/DPPC containing 0% (black), 20% (red), 30% (blue), and 40% (green) cholesterol. Experiments were performed at 25°C in 10 mM phosphate buffer, 100 mM NaCl, pH 7.4. All results are the average of three experiments. To see this figure in color, go online.