Table2.

Papers evaluating miRNA changes to differentiate healthy donors (HD) from MGUS and MM. Those in bold have been replicated in different studies.

Author	MiRNA increased	MiRNA decreased	Comment
Besse 82	MiR-130a		Elevated in patients with extra-medullary disease over MM
Navarro 83	-	MiR-16, miR-17, miR-19b, miR-20a, miR-660	MiRNA levels increased in patients achieving CR but did not reach healthy normal
Wang 84	-	Let7a, let7b, let7i, miR-15a, miR-15b, miR-16, miR-20a, miR-21, miR-106b, miR-223, miR-361	4 of 11 reduced in MGUS,8 of 11 reduced in SMM, 11 of 11 reduced in MM - suggests progressive 'accumulation' of miRNA dysregulation with progressive disease
Sevcikova 85	MiR-142-5p, miR-660, miR-29a
Huang 86	MiR-148a, miR-181a, miR20a, miR221, miR-99b		MiR20a finding conflicts with other groups
Kubiczkova 87	MiR-34a	Let7d, let7e, miR-130a, miR-744	Combination of let7e and miR-744 provided best ROC characteristics to differentiate HD and either MGUS or MM
Jones 88	MiR-720, miR-1246	MiR-1308	Different combinations of the three required to differentiate HD from MGUS or MM
Hao 89	MiR-4254	MiR-19a	Combination could distinguish HD or MM
Lionetti 90	42 upregulated	41 downregulated	Differentiate MM & PCL