Table1.

Characteristic of the five main histological subtypes of OC

	HGS	Endometrioid	Clear cell	Mucinous	LGS
Early stage: FIGO stage I or II; advanced stage: FIGO stage III-IV; amp: amplification
Approximate proportion of OC cases	70%	10%	10%	<5%	<5%
Overall prognosis	Poor	Favourable	Intermediate	Intermediate	Intermediate
Tissue of origin / precursor lesion	Distal fallopian epithelium	Endometriosis	Endometriosis	Poorly defined	Serous borderline tumor
Intrinsic chemosensitivity	High	High	Low	Low	Low
Associated hereditary syndromes	Germline BRCA1/2	Lynch syndrome	Lynch syndrome
Typical stage at diagnosis	80% advanced stage	50% early stage	60% early stage	80% early stage	Typically advanced stage
Frequent molecular abnormalities	Chromosome instability BRCA1, BRCA2 TP53, NF1, RB1 CCNE1 amp.	PTEN, PIK3CA, ARID1A, CTNNB1	PTEN, PIK3CA, ARID1A, chr20q13.2, amp	KRAS, HER2 amp	KRAS, BRAF