Table 2.
Characteristics of Ambulatory, Stable Patients With HFpEF
| Values | Normal Values | |
|---|---|---|
| Clinical characteristics | ||
| Age, yrs | 65 ± 2 | |
| Male/female | 45/55 | |
| Race | ||
| White | 23 | |
| Black | 74 | |
| Other (Asian, unknown, Hispanic) | 3 | |
| Etiology of HFpEF | ||
| Ischemic | 3 | |
| Hypertensive/nonischemic/unknown | 97 | |
| Comorbidities | ||
| Obesity: body mass index >30 kg/m2 | 90 | |
| Hypertension | 90 | |
| Type 2 diabetes mellitus | 58 | |
| Systolic blood pressure, mm Hg | 129 ± 26 | |
| Diastolic blood pressure, mm Hg | 75 ± 10 | |
| Heart rate, beats/min | 79 ± 2 | |
| QRS duration, ms | 103 ± 24 | |
| NYHA functional class | 2.1 ± 0.1 | |
| Echocardiography | ||
| LVEF, % | 63 ± 1 | |
| IVS, mm | 11.5 ± 0.5 | 7–11 |
| PW, mm | 11.3 ± 0.4 | 6–11 |
| LVEDD, mm | 45.5 ± 1.1 | <57 |
| LVESD, mm | 31 ± 13 | 21–40 |
| RWT | 0.50 ± 003 | 0.22–0.42 |
| LV mass, g | 187.5 ± 9 | 67–162 |
| LAVI, ml/m2 | 38.1 ± 5 | 16–34 |
| Diastolic function | ||
| Normal | 32 | |
| Grade I diastolic dysfunction | 42 | |
| Grade 2 diastolic dysfunction | 23 | |
| Grade 3 diastolic dysfunction | 3 | |
| Laboratory values | ||
| Cardiac TnI, mg/ml | 0.025 ± 0.005 | <0.033 |
| BNP, pg/ml | 242 ± 47 | <100 |
| Creatinine, mg/dl | 1.44 ± 0.13 | 0.7–1.3 |
| MDRD eGFR, ml/min/1.73 m2 | 51.6 ± 2.6 | >60 |
| Sodium, mmol/l | 139 ± 0.8 | 135–145 |
| Glucose, mg/dl | 136 ± 15 | 70–100 |
Values are mean ± SD for continuous variables or numbers or percent (%) for categorical variables. Normal values represent normals from 2D echocardiographic parameters and standard normal values for routine laboratory. Grade I diastolic dysfunction: impaired relaxation; grade 2 diastolic dysfunction: pseudonormal filling pattern; and grade 3 diastolic dysfunction: reversible restrictive filling pattern.
BNP = brain natriuretic peptide; IVS = intraventricular septal thickness; LAVI = left atrial volume index; LV = left ventricular; LVEDD = left ventricular end-diastolic diameter; LVEF = left ventricular ejection fraction; LVESD = left ventricular end-systolic diameter; MDRD eGFR = glomerular filtration rate by Modification of Diet in Renal Disease equation; NYHA = New York Heart Association; PW = posterior wall thickness; RWT = relative wall thickness; TnI = troponin I.