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. Author manuscript; available in PMC: 2017 Jun 15.
Published in final edited form as: Cancer Res. 2016 May 23;76(12):3484–3495. doi: 10.1158/0008-5472.CAN-15-2663

Figure 6. Model of integrin beta3 signaling pathway in tumor-associated macrophages.

Figure 6

(A) A negative feedback loop, in which integrin beta3 expression is induced in M2 macrophages by STAT6 activation, but integrin beta3 signaling suppresses STAT6 and promotes STAT1 activation. (B) In the tumor microenvironment, integrin beta3 signaling is a negative regulator of M2 TAM function. Blocking integrin beta3 signaling enhances tumor-promoting function in M2 TAMs.