Figure 3.

(A) Superimposition of snapshots from the 1-μs simulation of cTnC at 28°C, with helices labeled N, A, B, C, and D. The most open conformation from this simulation is shown in blue and the most closed conformation is shown in white. (B) Angles are drawn onto the superimposed and isolated A and B helices. (C) The helices are superimposed with equivalent structures from the NMR-derived human cTnC structures in the Ca²⁺-free, closed form (PDB: 1SPY), shown in red, and in the open conformation in complex with the TnI switch peptide (PDB: 1MXL), shown in green. To see this figure in color, go online.