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. 2016 Jul 6;95(1):109–119. doi: 10.4269/ajtmh.15-0804

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©The American Society of Tropical Medicine and Hygiene

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Figure 4. — Effect of leptin administration on pro-inflammatory immune response in Leishmania donovani-infected Ob/Ob mice. (A) Interferon gamma, interleukin (IL)12p70, and IL10 were measured from the Leishmania FTAg–stimulated splenocytes culture supernatants using multiplex enzyme-linked immunosorbent assay. (B) Anti-Leishmania antibody IgG1 and ratio of IgG2a/IgG1 level from the plasma of leptin treated and untreated L. donovani-infected mice 60 days postinfection. Cumulative data of two independent experiments are shown (N = 7).