Figure 2.

A, Multiple axial images from chest CT imaging in a 57-year-old man with GT genotype at the rs35705950 single-nucleotide polymorphism (SNP) show mild basilar and peripheral predominant pulmonary fibrosis characterized by ground-glass opacity, reticulation, and traction bronchiectasis without subpleural honeycombing. These CT scans were scored as indeterminate usual interstitial pneumonitis (UIP) given the low level of confidence in making a UIP diagnosis. B, Multiple axial images from chest CT imaging in a 62-year-old woman with GG genotype at the rs35705950 SNP show mild peripheral and basilar predominant reticulation and traction bronchiectasis without subpleural honeycombing. There is moderate degree of mosaic attenuation (arrows) in the basilar left lower lobe and mild mosaic attenuation in the right lower lobe, shown to represent air trapping on expiratory images (not shown). These CT scans were scored as indeterminate UIP given the borderline degree of air trapping.