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. Author manuscript; available in PMC: 2017 Apr 11.
Published in final edited form as: Angew Chem Int Ed Engl. 2016 Mar 9;55(16):4924–4927. doi: 10.1002/anie.201509989

Figure 3.

Figure 3

Omit FO-FC difference (purple mesh) neutron scattering length density maps (contoured at 3.0 σ) for the HIV-1 protease catalytic site at pH 6.0 (left) and pH 4.3 (right).A two-proton transfer has occurred; i.e. D1 on Asp25’ has moved to the OH of darunavir and D2 has been transferred to Asp25. D atoms are coloured teal, and H atoms of darunavir are omitted for clarity. Distances are in Å.