Table 1.

Definition of APEs at OHSU Doernbecher Pediatric CF Center.

Pulmonary signs and symptoms*	Increased cough ≥1 week Increased chest congestion Crackles or wheezes on exam New or increased hemoptysis Dyspnea Decrease in FEV1 by10–15% Chest pain
Systemic signs and symptoms	Malaise Fever Lethargy/fatigue Anorexia Weight loss Sinus pain/tenderness Sinus discharge

Note:

^*A treatable exacerbation would need to include any or all of the pulmonary findings.