A Chemical structure of CCT128930 (4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine)
B X-ray crystal structure of CCT128930 bound to PKA-AKT chimeric protein (PDB code 2V06; (12)). The inhibitor (amber) and key residues in the ATP-binding site (grey) are shown with hydrogen-bonding interactions indicated (dashed lines). The residue targeted by CCT128930 to give selective inhibition of AKT over PKA is highlighted (Met173 in PKA-AKT chimera, equivalent to Met282 in AKT) (12, 13).