Table 3.
Multiple Cox's proportional hazards analysis for the risk factors of metachronous SCC after ESD
| Risk factor | Metachronous cases | Without metachronous cases | Hazard ratios | 95% CI | P‐value |
|---|---|---|---|---|---|
| Multiple LVLs | 34 | 65 | 0.09 | ||
| Heavy alcohol consumption | 25 | 38 | 1.35 | 0.64–3.13 | 0.45 |
| Smoking | 30 | 53 | 3.38 | 1.28–11.68 | 1.19 × 10−2 |
| ALDH2; rs671 GA | 30 | 50 | 3.28 | 1.28–11.15 | 1.08 × 10−2 |
| ADH1B; rs1229984 GG | 17 | 14 | 2.21 | 1.10–4.45 | 2.59 × 10−2 |
Herein, 34 patients with metachronous SCC and 83 patients without metachronous SCC after endoscopic resection were analyzed.
All patients with metachronous SCC had multiple LVLs.
Hazard ratios and CIs were calculated using the nonrisk environmental factors and nonsusceptible allele as a reference.
LVLs, Lugol‐voiding lesions; CI, confidence interval; CRT, chemoradiotherapy; SCC, squamous cell carcinoma.