Table 3.
Area under the receiver operating characteristic curve (AUC) and the cutoff value for each biomarker that would give the test at least a 95% sensitivity for detecting group B streptococcus (GBS) III and Ia stimulation, with the corresponding specificity
| GBS III AUC (95% CI) | Cutoff value | GBS Ia AUC (95% CI) | Cutoff value | |
|---|---|---|---|---|
| LSR | ||||
| CD11b–Gr | 1.00 (1.00–1.00) | 8,035 Spec 1.00 | 0.92 (0.84–1.00) | 4,270 Spec 0.65 |
| CD11b–Mo | 0.93 (0.84–1.00) | 4,092 Spec 0.85 | 0.83 (0.70–0.95) | 2,766 Spec 0.50 |
| CD64–Gr | 0.76 (0.61–0.90) | 473 Spec 0.48 | 0.50 (0.32–0.68) | 254 Spec 0.00 |
| TLR2 | 0.88 (0.76–0.99) | 1,151 (Sens 1.0) Spec 0.67 | 0.70 (0.54–0.86) | 926 Spec 0.33 |
| TLR4 | 0.53 (0.34–0.73) | 1,118 Spec 0.21 | 0.39 (0.21–0.57) | 898 Spec 0.00 |
| TLR6 | 0.69 (0.52–0.86) | 1,661 Spec 0.40 | 0.55 (0.37–0.74) | 1,231 Spec 0.20 |
| SIB | ||||
| IL-8 | 1.00 (1.00–1.00) | 5,292 Spec 1.00 | 1.00 (0.98–1.00) | 4,190 Spec 1.00 |
| Il-6 | 0.99 (0.97–1.00) | 197 Spec 0.95 | 0.97 (0.91–1.00) | 70 Spec 0.90 |
| IP-10 | 0.60 (0.42–0.78) | 52 Spec 0.15 | 0.51 (0.41–0.77) | 44 Spec 0.05 |
| S100b | 0.43 (0.25–0.61) | 306 Spec 0.00 | 0.46 (0.28–0.64) | 312 Spec 0.00 |
Abbreviations: CI, confidence interval; Gr, granulocyte; Mo, monocyte; LSR, leukocyte surface receptors; SIB, soluble inflammatory biomarkers; Spec, specificity; Sens, sensitivity; TLR, toll-like receptor; IL, interleukin; IP, interferon-γ-inducing protein.