Table 1.

Preconception risk assessment for SLE patients

Contraindications of pregnancy6

History of severe preeclampsia despite aspirin and heparin use

Heart failure

Restrictive lung disease (FVC <1 L)

Renal insufficiency (Cr >2.8 mg/dL)

Severe pulmonary hypertension (sPAP >50 mmHg)

Suspend pregnancy until stable for 6 months

Active lupus nephritis

Recent SLE flare

High-risk patients

Active lupus nephritis or SLE flare within 6 months

APS

Anti-SS-A or SS-B antibodies

Low-risk patients

No history of severe organ damage

Quiescent disease at conception

Abbreviations: SLE, systemic lupus erythematosus; FVC, forced vital capacity; Cr, creatinine; sPAP, systolic pulmonary artery pressure; APS, antiphospholipid syndrome.