Table 2.
Effects of paeoniflorin (Pa) and menthol (Me) on puerarin (Pu) transport in Calu-3 cells
| Condition (μg/mL) | Papp (A→B) (×10−6 cm/s) | Papp (B→A) (×10−6 cm/s) | ER (B→A/A→B) |
|---|---|---|---|
| Pu (60) (control) | 1.226±0.039 | 1.240±0.055 | 1.012±0.032 |
| +Pa (12) | 1.240±0.027 | 1.242±0.037 | 1.002±0.039 |
| +Pa (24) | 1.233±0.054 | 1.254±0.032 | 1.018±0.065 |
| +Pa (48) | 1.229±0.025 | 1.289±0.035 | 1.049±0.027 |
| +Me (15) | 1.285±0.084 | 1.363±0.083 | 1.065±0.116 |
| +Me (30) | 1.639±0.058* | 1.803±0.111* | 1.100±0.060 |
| +Me (60) | 1.788±0.087* | 2.067±0.151* | 1.157±0.088 |
| +Pa (12) + Me (15) | 1.305±0.150 | 1.288±0.067 | 0.999±0.150 |
| +Pa (24) + Me (30) | 1.559±0.143* | 1.910±0.254* | 1.228±0.157 |
| +Pa (48) + Me (60) | 1.957±0.067* | 2.136±0.130* | 1.091±0.048 |
Notes: Papp, permeability; A, apical side; B, basolateral side. Values shown as mean ± SD (n=3). Differs from Pu (60 μg/mL):
*
P<0.05.
Abbreviations: ER, efflux ratio; s, seconds; SD, standard deviation.