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. 2016 Jul 14;11(7):e0159457. doi: 10.1371/journal.pone.0159457

Table 6. LOOCV results for 165 polygenic disease, based on the combination of Tanimoto and mimMiner in different proportions.

Proportion of Tanimotoa Best C valueb MRR, % Top-ranking genesc TPR in the top 5, % TPR in the top 10, % TPR in the top 30, %
0.3 -17 7.78 93 45.20 54.80 66.74
0.4 -17 7.76 94 44.50 54.80 66.28
0.5 -16 7.75 96 43.09 51.99 64.87
0.6 -16 7.75 94 42.62 51.99 64.40
0.7 -16 7.75 93 41.22 51.05 65.34

MRR, mean rank ratio; TPR, true positive rate

a proportion of mimMiner = 1.0—proportion of Tanimoto.

b the best C value will be obtained when maximum number of top-ranking genes is reached.

c it signifies the maximum number of target genes ranked on top of the candidate list. Totally, there are 427 target genes in LOOCV for polygenic diseases.