Table 3. Forty-six DCPs, including 29 down-regulated proteins (log FC < -1) and 17 up-regulated proteins (log FC > 1).
| Gene symbol | Protein Name | Log FC* |
|---|---|---|
| FGB | Fibrinogen beta chain | 4.08 |
| CFH | Complement factor H | 3.14 |
| FN1 | Isoform 10 of Fibronectin | 3.23 |
| ITIH4 | Inter-alpha-trypsin inhibitor heavy chain H4 | 3.31 |
| FGG | Isoform Gamma-A of Fibrinogen gamma chain | 4.27 |
| HP | Haptoglobin | 4.28 |
| IGHA1 | Ig alpha-1 chain C region | 3.17 |
| AFM | Afamin | 3.15 |
| IGHM | Isoform 2 of Ig mu chain C region | 3.65 |
| LUM | Lumican | 2.26 |
| SERPINA7 | Thyroxine-binding globulin | 1.67 |
| VTN | Vitronectin | 2.77 |
| ITIH1 | Inter-alpha-trypsin inhibitor heavy chain H1 | 1.65 |
| APOC1 | Apolipoprotein C-I | 3.96 |
| SAA4 | Serum amyloid A-4 protein | 1.41 |
| F12 | Coagulation factor XII | 1.54 |
| S100A6 | Protein S100-A6 | 1.51 |
| RBP3 | Retinol-binding protein 3 | -4.06 |
| TTR | Transthyretin | -1.58 |
| CTSD | Cathepsin D | -3.14 |
| CST3 | Cystatin-C | -2.12 |
| MYOC | Myocilin | -3.47 |
| GPX3 | Glutathione peroxidase 3 | -2.64 |
| CRYBB1 | Beta-crystallin B1 | -4.14 |
| SEMA7A | Semaphorin-7A | -3.06 |
| CPE | Carboxypeptidase E | -2.77 |
| C1S | Complement C1s subcomponent | -1.64 |
| ENPP2 | Isoform 3 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | -1.89 |
| CRYBB2 | Beta-crystallin B2 | -3.91 |
| CLSTN1 | Isoform 2 of Calsyntenin-1 | -2.06 |
| CRYGS | Beta-crystallin S | -5.42 |
| SOD3 | Extracellular superoxide dismutase [Cu-Zn] | -2.94 |
| B3GNT1 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase | -1.77 |
| FAM3C | Protein FAM3C | -3.18 |
| CDH2 | Cadherin-2 | -2.47 |
| CRYGD | Gamma-crystallin D | -3.64 |
| WIF1 | Wnt inhibitory factor 1 | -2.37 |
| COL9A1 | Collagen alpha-1(IX) chain | -2.42 |
| IGFBP6 | Insulin-like growth factor-binding protein 6 | -1.37 |
| CRYBA1 | Beta-crystallin A3 | -4.23 |
| MFAP4 | Isoform 2 of Microfibril-associated glycoprotein 4 | -2.00 |
| SEMA4B | Semaphorin-4B | -2.14 |
| ASAH1 | Isoform 2 of Acid ceramidase | -2.61 |
| CTSA | Lysosomal protective protein | -1.77 |
| ALDH1A1 | Retinal dehydrogenase 1 | -1.89 |
| IMPG1 | Interphotoreceptor matrix proteoglycan 1 | -3.32 |
* log FC, log2 of the average protein level fold change (FC) in the samples from stage 3A, stage 3B and stage 4 Coats’ disease patients.