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. 2016 Jul 14;11(7):e0159138. doi: 10.1371/journal.pone.0159138

Fig 7. Evaluation of the effect of different normalization approaches on samples and variables in the data, shown in both sample mode and variable mode.

Fig 7

(A) Un-normalized log2 data. (B) Subtract by group mean + semi-global normalization. (C) ComBat + semi-global normalization. (D) Global VSN + Combat normalization. (E) Global LOESS + Combat normalization