Table 6. Evaluation of four methods for defining a condensed biomarker signature for classification of two groups.

Once the biomarker signature of the optimal length was defined using the validation set, the classifier was re-trained, using both the training and the validation set and finally tested on the test set. Sample cohort 3 was used.

Method	Biomarker length	ROC AUC
		Validation set	Test set
p-value	30	92.2	90.6
BE-SVM	30	93.6	92.7
SVMc	40	93.9	94.0
RF (SVM)	45	93.9	93.1