Table 3. Cox proportional hazards regression analysis for MACCE.
| Variable | Simple | Multiple | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | |
| Age | 1.041 | 1.025–1.058 | <0.0001 | 1.013 | 0.994–1.033 | 0.181 |
| Male gender | 0.788 | 0.498–1.247 | 0.309 | |||
| Diabetes | 1.726 | 1.134–2.626 | 0.011 | 1.459 | 0.869–2.450 | 0.153 |
| Hypertension | 2.355 | 1.518–3.656 | <0.0001 | 1.800 | 1.054–3.074 | 0.031 |
| Dyslipidemia | 1.259 | 0.795–1.994 | 0.326 | |||
| Multi-vessel disease | 1.765 | 1.133–2.750 | 0.012 | 1.237 | 0.724–2.113 | 0.437 |
| Killip class 4 | 3.874 | 2.328–6.447 | <0.0001 | 1.692 | 0.789–3.627 | 0.177 |
| Heart rate | 1.015 | 1.007–1.023 | <0.0001 | |||
| LVEF | 0.940 | 0.921–0.960 | <0.0001 | 0.954 | 0.932–0.976 | <0.0001 |
| CI-AKI | 3.558 | 2.247–5.634 | <0.0001 | |||
| HLI | 2.445 | 1.617–3.697 | <0.0001 | |||
| Combined CI-AKI & HLI | 8.995 | 4.989–16.219 | <0.0001 | 4.996 | 2.309–10.811 | <0.0001 |
Abbreviations. CI = confidence interval; CI-AKI = contrast induced acute kidney injury; HLI = hypoxic liver injury; HR = hazard ratio; LVEF = left ventricular ejection fraction; MACCE = major adverse cardiovascular and cerebrovascular event; MI = myocardial infarction; TLR = target lesion revascularization; TVR = target vessel revascularization.